Transition to failure

Although studied since decades, cardiovascular diseases remain the number one cause of death worldwide. As a first response to stress, the heart develops hypertrophy during most diseases. Cardiac hypertrophy is characterized by an increase in heart mass as a response to mechanical stress caused by volume or pressure overload in the ventricles. Initially the heart is able to compensate a stress stimulus. However, if the stress factors persist over time, compensated hypertrophy can turn into heart failure as a consequence of deleterious processes like inflammation, apoptosis and fibrosis. Heart failure is a poorly reversible state and will eventually lead to death. During the last ten years, no progress in the development of new therapies in the treatment of the transition to heart failure could be achieved. This might be due to the fact that specific, local therapeutic pathways were not identified in the past.
The aim of our lab is to better understand the molecular basis of the transition to heart failure. Therefore, we carry out deep high-throughput sequencing on genome and transcriptome level of myocardium of patients in the transition to failure. The identified candidates are analyzed for there association to molecular pathways and networks. Furthermore, their relevance in the transition process is tested in-vitro in human cardiomyocytes and in-vivo in mouse models.

Better understanding of the pathophysiological mechanisms underlying the transition to failure might enable the development of new therapeutic strategies, which eventually allow an early intervention in the transition process.
 

Contact
Prof. Dr. Gerd Hasenfuß
Prof. Dr. Gerd Hasenfuß
Director of the Clinic for Cardiology and Pneumology / Group leader
Phone:
0551 39-20400
E-Mail:
rfaber@med.uni-goettingen.de
Sara Khadjeh
Dr. rer. nat. Sara Khadjeh
Deputy Head of Working Group
Phone:
0551-39-63633
Fax:
0551-39-22953
E-Mail:
sara.khadjeh@med.uni-goettingen.de
Vanessa Kernke
PhD student
Phone:
0551-39-63633
E-Mail:
vanessa.kernke@med.uni-goettingen.de
Frederike Weber
PhD student Cand. med.
Phone:
0551-39-63633
E-Mail:
Frederike.Weber@med.uni-goettingen.de
Anke Bode
Technical assistant
Phone:
0551-39-63663
E-Mail:
anke.bode@med.uni-goettingen.de