Molecular cardiology

Our group focuses on molecular mechanisms of signal transduction in cardiomyocytes. Our main interest is the analysis of pathways regulation affecting hypertrophic growth and heart failure. In particular, we investigate modulators of the mitogen activated protein kinase (MAPK)-pathway and the Calcineurin pathway applying molecular biology methodology including cell culture, protein biochemistry and transgenic and knock-out models. Our junior scientist group consists of medical and biology students, technicians, PhD students, post-docs as well as physicians.
MAPK signaling plays an important role in critical cellular processes including growth, differentiation, mitosis and apoptosis and modulates cardiac signal transduction. MAP-kinases are activated by mechanical and neurohumoral stimulation in cardiomyocytes and modulate signals of physiologic heart function and hypertrophy. Furthermore, the NFAT-Calcineurin pathway is of critical importance for cardiac hypertrophy. Our aim is to understand the complex regulation of activation and inhibition of these pathways to develop suitable therapies. Thus we analyse BRAP, an important modulator of MAPK signaling. Our previous work in vitro and in vivo suggests that BRAP can modulate hypertrophic growth in the heart. To investigate the regulation of the NFAT-Calcineurin pathway we are focussing on the protein Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A), an important kinase of the transcription factor NFAT (Nuclear Factor of activated T-Cells). The phosphatase Calcineurin dephosphorylates NFAT, thereby inducing expression of many genes leading to maladaptive hypertrophy. Thus we are analysing if DYRK inhibits maladaptive hypertrophy in cardiac myocytes.
Our work is supported by grants from the German Research Foundation (DFG) and the European Union (FP6 project "EUGeneHeart").

Teammitglieder Arbeitsgruppe Molekulare Kardiologie

Contact
PD Dr. Tim Seidler
Head of working group
Abteilung:
WG Molecular cardiology
Phone:
0551-39-66380
Pager:
919-2095
Fax:
0551-39-22953
E-Mail:
tim.seidler@med.uni-goettingen.de
Jessica Spitalieri
Medical laboratory technician
Phone:
0551-39-66340
E-Mail:
jspitali@med.uni-goettingen.de
Gudrun Müller
Medical laboratory technician
Phone:
0551-39-66340
E-Mail:
gudmueller@web.de
Simon Grau
Phone:
0551-39-66340
E-Mail:
simon.grau@stud.uni-goettingen.de
Sebastian Bremer
Phone:
0551-39-66340
E-Mail:
sebastian.bremer@stud.uni-goettingen.de
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